[12] Patent
[11] Patent No.:GC0011351  
[45] Date of Publishing the Grant of the Patent: 31/Jul /2020                72/2020  
Number of the Decision to Grant the Patent:2020/170247
Date of the Decision to Grant the Patent:02/Jul/2020

[21] Application No.:GC 2015-29119

[22] Filing Date:25/3/2015

[30] Priority:

[33] State [32] Priority date [31] Priority No.
EP
26/3/2014
14161756.3

[72] Inventors:1- Daniel Hunziker،2- Jérôme Hert،3- Holger Kuehne،4- Patrizio Mattei،5- Markus Rudolph

[73] Owner: F. Hoffmann - La Roche AG, 124 Grenzacherstrasse , Basle , Switzerland

[74] Agent: Kadasa Law Firm

  

 

  

[51]IPC:
Int. Cl.: A61K 31/551; A61P 1/16, 3/00, 37/08; C07D 487/04 (2006.01)

[56] Cited Documents:

BARBAYIANNI EFROSINI ET AL: “Autotaxin inhibitors: a patent review,
EXPERT OPINION ON THERAPEUTIC PATENTS,
INFORMA HEALTHCARE, UNITED KINGDOM,
vol. 23, no. 9, 1 September 2013 (2013-09-01), pages
1123-1132, XP009172423
-HARALD M. H. G. ALBERS ET AL: Chemical Evolution of Autotaxin Inhibitors,
CHEMICAL REVIEWS,
vol. 112, no. 5, 9 May 2012 (2012-05-09), pages 2593-2603, XP055073234
-WO 2011006569 A1 (MERCK PATENT GMBH [DE]; SCHULTZ MELANIE [DE]; SCHIEMANN KAI [DE]; STAE) 20 January 2011
-WO 2011151461 A2 (B S R C ALEXANDER FLEMING [GR]; AIDINIS VASSILIOS [GR] ) 8 December 2011
 
Examiner: PH. Mohammad S. AlMousa

[54] CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN ATX AND LYSOPHOSPHATIDIC ACID LPA PRODUCTION INHIBITORS
[57] Abstract: The invention provides novel compounds having the general formula (I) (I)wherein R1, R2, A1and A2 are as described herein, compositions including the compounds and methods of using the compounds.
No. of claims: 28


 

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