[12] Patent
[11] Patent No.:GC0004562  
[45] Date of Publishing the Grant of the Patent: 31/Dec /2016                32/2016  
Number of the Decision to Grant the Patent:2016/90181
Date of the Decision to Grant the Patent:27/Dec/2016

[21] Application No.:GCC/P/2008/11693

[22] Filing Date:10/9/2008

[30] Priority:

[33] State [32] Priority date [31] Priority No.
DK
11/9/2007
PA200701314

[72] Inventors:1- Carla De Faveri ،2- Florian Anton Martin Huber،3- Robert James Dancer

[73] Owner: H. LUNDBECK A/S, 9 Ottiliavej, Valby, DK -2500, Denmark

[74] Agent: Suleiman I. Al-Ammar Law Office

  

 

  

[51]IPC:
Int. Cl.: C07C 253/34, 255/53; C07D 307/87 (2006.01)

[56] Cited Documents:

-WO 2005/106531 A (JUBILANT ORGANOSYS LTD{IN}; GOANKAR SANTOSH LAXfiAN [IN]; DASPRASENJI) 12 October 2006
-EP 0 347 066 A (LUNDBECK & CO AS H [DKJJ20 December 1989
-WO 2007/012954 A (AUROBINDO PHARflA LTD[IN]; KAUSHIK VIPIN KUMRR [IN]; KHANMOHAMMEa UNA) 1 February 2007
 
Examiner: PH. Nada A. AlShamrani

[54] METHOD FOR MANUFACTURE OF ESCITALOPRAM
[57] Abstract: This patent discloses a method for resolution of 4-[4-(dimethylamino)-1 (4´ fluorophenyl)-1 hydroxy¬butyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallising 4 [4-(dimethylamino)-1 (4´ fluoro¬phenyl)-1 hydroxy¬butyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S)- or (-)-(R,R)-enantiomer of O,O’-di-p-toluoyl¬-tartaric acid in a solvent system comprising 1 propanol, ethanol or acetonitrile.
No. of claims: 19


 

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