[12] Patent
[11] Patent No.:GC0011495  
[45] Date of Publishing the Grant of the Patent: 30/Nov /2020                76/2020  
Number of the Decision to Grant the Patent:2020/174768
Date of the Decision to Grant the Patent:11/Nov/2020

[21] Application No.:GCC/P/2009/14493

[22] Filing Date:13/10/2009

[30] Priority:

[33] State [32] Priority date [31] Priority No.
US
US
US
US
14/10/2008
12/2/2009
22/4/2009
25/6/2009
61/105,086
61/152,131
61/171,768
61/220,514

[72] Inventors:1- Lisa A. DAMICO،2- Napoleone FERRARA،3- Henry B. Lowman،4- Yu-Ju G. Meng،5- Yik Andy Yeung

[73] Owner: GENENTECH, INC., 1 DNA Way, California 94080 , South San Francisco, USA

[74] Agent: Suleiman I. Al-Ammar Law Office

  

 

  

[51]IPC:

[56] Cited Documents:

-DALL' ACQUA WILLIAM F ET AL: Increasing
the affinity of a human IgG1 for the
neonatal Fe receptor: Biological
consequences
JOURNAL OF IMMUNOLOGY, AMERICAN
ASSOCIATION OF IMMUNOLOGISTS, US,
vol. 169, no. 9,
1 November 2002
-WO 02/060919 A2 (MEDIMMUNE INC [US]; DALL
ACQUA WILLIAM [US]; JOHNSON LESLIE S [US];
WA) 8 August 2002
-WO 2006/053301 A2 (XENCOR INC [US];
CHAMBERLAIN AARON KEITH [US]; DESJARLAIS
JOHN R [US];) 18 May 2006
-WO 2006/031370 A2 (GENENTECH INC [US];
LOWMAN HENRY B [US]; ADAMS CAMELLIA W
[US]; MARVIN) 23 March 2006
-WO 97/34631 AI (UNIV TEXAS [US]; WARD
ELIZABETH SALLY [US])
25 September 1997
-WO 00/42072 A2 (GENENTECH INC [US])
20 July 2000
-YEUNG YIK ANDY ET AL: Engineering Human
IgG1 Affinity to Human Neonatal Fe
Receptor: Impact of Affinity Improvement
on Pharmacokinetics in Primates
JOURNAL OF IMMUNOLOGY,
vol. 182, no. 12, June 2009
-WO 2009/086320 Al (XENCOR INC [US];
CHAMBERLAIN AARON [US]; DAHIYAT BASSIL
[US]; DESJARLA) 9 July 2009
-WO 2009/058492 A2 (XENCOR INC [US];
CHAMBERLAIN AARON [US]; DAHIYAT BASSIL
[US]; DESJARLA) 7 May 2009
 
Examiner: PH. Neda J. AlMuallem

[54] IMMUNOGLOBULIN VARIANTS AND USES THEREOF
[57] Abstract: Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.
No. of claims: 19     No. of figures: 28


 

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