[12] Patent
[11] Patent No.:GC0009316  
[45] Date of Publishing the Grant of the Patent: 31/Dec /2018                56/2018  
Number of the Decision to Grant the Patent:2018/141275
Date of the Decision to Grant the Patent:10/Dec/2018

[21] Application No.:GC 2011-20045

[22] Filing Date:17/12/2011

[30] Priority:

[33] State [32] Priority date [31] Priority No.
US
17/12/2010
61/424.601

[72] Inventors:1- William H. Roark،2- Chitase Lee،3- Gary L. Bolton،4- Melean Visnick،5- Eric Anderson،6- Xin Jiang،7- Bradley Caprathe

[73] Owner: Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, TX 75063-2648, Irving, USA

[74] Agent: Suleiman I. Al-Ammar Law Office

  

 

  

[51]IPC:
Int. Cl.: C07C 255/47; C07D 231/54, 239/70, 401/04, 403/04, 413/04, 417/04, 487/04 (2006.01)

[56] Cited Documents:

-WO 2009/146216 A2 (REATA PHARMACEUTICALS INC [US]; JIANG XIN [US]; GREINER JACK; MARAVETZ) 03 December 2009
-HONDA T ET AL: New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 7, no. 13, 08 July 1997
 
Examiner: PH. Nada A. AlShamrani

[54] PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS
[57] Abstract: Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: (I),wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
No. of claims: 112


 

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