[12] Patent
[11] Patent No.:GC0007599  
[45] Date of Publishing the Grant of the Patent: 30/Apr /2018                48/2018  
Number of the Decision to Grant the Patent:2018/126084
Date of the Decision to Grant the Patent:16/Apr/2018

[21] Application No.:GC 2013-24940

[22] Filing Date:14/7/2013

[30] Priority:

[33] State [32] Priority date [31] Priority No.

[72] Inventors:1- Georg Jaeschke،2- Lothar Lindemann،3- Heinz Stadler،4- Eric Vieira

[73] Owner: F. Hoffmann-La Roche AG, 124 Grenzacherstrasse, CH-4070, Basle, Switzerland

[74] Agent: Kadasa Law Firm




Int. Cl.: C07D209/52, A61K31/403, A61P25/00 (2006.01)

[56] Cited Documents:

-WO 2011/128279 Al (HOFFMANN LA ROCHE [CH] ;GREEN LUKE [CH] ; GUBA WOLFGANG [DE] ; JAESCHKE) 20 October 2011  
Examiner: PH. Bashair Z. AlEnizi

[57] Abstract: The present invention relates to ethynyl derivatives of formula I I whereinR1is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine;or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
No. of claims: 8


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