[12] Patent
[11] Patent No.:GC0007585  
[45] Date of Publishing the Grant of the Patent: 30/Apr /2018                48/2018  
Number of the Decision to Grant the Patent:2018/126036
Date of the Decision to Grant the Patent:15/Apr/2018

[21] Application No.:GCC/P/2006/6495

[22] Filing Date:27/6/2006

[30] Priority:

[33] State [32] Priority date [31] Priority No.
EP
28/6/2005
05105762.8

[72] Inventors:1- Lancois, David Francis Alain،2- Backx, Leo Jacobus Jozef،3- Andries, Koenraad Jozef Lodewijk Marcel،4- Motte, Magali Madeleine Simone،5- Dorange, Ismet،6- Koul. Anil،7- Guillemont , Jerome Emile Georges،8- Meerpoel, Lieven

[73] Owner: JANSSEN PHARMACEUTICA N. V., Turnhoutseweg 30, B 2340, Beerse, Belgium

[74] Agent: Kadasa Law Firm

  

 

  

[51]IPC:
Int. Cl.: A61K 31/47 (2006.01)

[56] Cited Documents:

- WO 2004011436 A (JANSSEN PHARMACEUTICA N.V; VAN GESTEL, JOZEF, FRANS, ELISABETHA; GUILL) 5 February 2004
-WO 2005033108 A (JANSSEN PHARMACEUTICA, N.V; BOWERS GRANT III, EUGENE; MACIELAG,MARK J) 14 April 2005
 
Examiner: Hanien H Al Ghannami

[54] QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
[57] Abstract: Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula ; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl ; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula -CH=CH-CH=CH-; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo ; or R8 and R9 together form the radical –CH=CH-N=.
No. of claims: 33


 

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